Proton pump inhibitors might cause serious kidney damage. New research published in the Journal of the American Society of Nephrology (JASN) indicates that long- term use of proton pump inhibitors (PPIs), commonly used to treat heartburn, acid reflux, and ulcers can have damaging effects on the kidneys. In 2. 01. 3, an estimated 1. Americans were prescribed PPIs, which reduce gastric acid production. This number is likely an underestimate because the medications are also available over- the- counter and can be purchased without prescription, according to background information for the study. A study published in JAMA Internal Medicine in January also showed a connection between the drugs and kidney damage. To assess the safety of this widely used drug class, a team led by Yan Xie, MPH and Ziyad Al- Aly, MD, FASN, from the Clinical Epidemiology Center at the VA Saint Louis Health Care System and Washington University in St. ![]() Louis, analyzed information from the Department of Veterans Affairs national databases. The investigators identified 1. PPIs and 2. 0,2. 70 new users of histamine H2 receptor blockers, an alternative class of drugs also used to suppress stomach acid. Over five years of follow- up, those taking PPIs were more likely to experience kidney function decline than those taking H2 receptor blockers. PPI users also had a 2. Furthermore, there was a graded association between duration of PPI use and risk of kidney problems, with those who took PPIs for a longer time being more likely to develop kidney issues. ![]() The findings suggest that long- term use of PPIs may be harmful to the kidneys and should be avoided. PPI use may not only increase the risk of developing chronic kidney disease, but may also increase the risk of its progression to complete kidney failure.“The results emphasize the importance of limiting PPI use only when it is medically necessary, and also limiting the duration of use to the shortest duration possible,” said Dr. Al- Aly.” A lot of patients start taking PPIs for a medical condition, and they continue much longer than necessary.”The results also provide insights for future investigations on drug safety. ![]() Find reliable, easy to understand information about cancer. Whether you have cancer or are supporting someone with it, we can guide you through diagnosis, treatment. A simple high-fiber diet can provide health benefits while being easier to stick with than a diet calling for multiple changes in eating habits, a new clinical trial. Do you suffer from gallbladder pain or gallstones? Many doctors suggest eating a so-called “low-fat” diet, taking drugs, and if trouble persists, having the. Nils July 12, 2012. Great post as always, thanks. However, I do think you might have overlooked one critical aspect of diet. The conversion of fructose to. Instead of commonly prescribed drugs, try these natural home remedies for the treatment of heartburn, acid reflux and ulcers. Note : The following represents the written instructions that we provide for our patients upon discharge at Georgetown University. Insulin is a drug prescribed to treat type 1 and type 2 diabetes. Common side effects include headache, nausea, tiredness, blurred vision, and excessive yawning. The Impact of Total Ischemic Time, Donor Age and the Pathway of Donor Death on Graft Outcomes After Deceased Donor Kidney Trans. Effect of Induction Therapy on. ![]() ![]()
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